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The relationship between chronic kidney disease and SYNTAX score
Ugur Coskun1, Kadriye Orta Kilickesmez, Okay Abaci
1Department of Cardiology, Istanbul University Institute of Cardiology, Haseki, Istanbul, Turkey. drugurcoskun@gmail.com
Angiology
|March 23, 2011
Summary
Chronic kidney disease (CKD) is linked to more severe coronary artery blockages. Lower kidney function, measured by estimated glomerular filtration rate (eGFR), predicts increased coronary lesion complexity.
Area of Science:
- Cardiology
- Nephrology
Background:
- Chronic kidney disease (CKD) significantly elevates cardiovascular disease (CVD) risk.
- CKD is a known independent risk factor for adverse cardiovascular outcomes.
Purpose of the Study:
- To investigate the association between CKD severity and coronary artery stenosis complexity.
- To determine if estimated glomerular filtration rate (eGFR) predicts coronary lesion complexity using the SYNTAX Score.
Main Methods:
- Coronary angiograms from 217 patients with left main and/or 3-vessel coronary artery disease were analyzed.
- Patients were categorized into five groups based on NKF KDOQI guidelines using pre-angiography eGFR.
- The SYNTAX Score was calculated to quantify coronary artery stenosis severity.
Main Results:
- A progressive increase in significant coronary lesion complexity was observed with declining kidney function (P = .001).
- Lower eGFR was a strong predictor of a higher SYNTAX Score, indicating more complex coronary artery disease.
Conclusions:
- CKD severity is directly associated with increased complexity of coronary artery stenosis.
- eGFR is a valuable predictor of coronary lesion complexity in patients undergoing angiography.
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