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Rates and risks of gastrostomy tubes in infants with cleft palate
1Department of Otolaryngology, Children's Hospitals and Clinics of Minnesota and University of Minnesota, Minneapolis, MN, USA.
Insights
Infants with cleft palate requiring gastrostomy (G)-tubes are significantly more likely to have comorbidities. Specific conditions like respiratory issues dramatically increase G-tube risk, guiding better feeding management strategies.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Genetics
Background:
- Cleft palate presents feeding challenges in infants.
- Gastrostomy (G)-tubes are sometimes necessary for nutritional support.
- Identifying risk factors for G-tube placement is crucial for management.
Purpose of the Study:
- Determine rates of G-tube placement in infants with cleft palate.
- Identify comorbidities contributing to G-tube necessity.
- Analyze relative risks to refine management strategies for feeding difficulties.
Main Methods:
- Retrospective review of medical records from a tertiary care children's hospital.
- Included infants with cleft palate born between 2000-2008 without prior G-tubes.
- Analyzed comorbidities including syndromes/chromosomopathies (syn/chrom) and cardiac, respiratory, neurologic, and GI diagnoses.
Main Results:
- 34 out of 214 infants with cleft palate required G-tubes.
- G-tube placement rates varied widely, from 3% (no comorbidity) to 94% (respiratory comorbidity).
- Relative risks for G-tube placement were significantly elevated with syn/chrom (5.68), single system comorbidity (21.79), and multisystem comorbidities (29.66).
Conclusions:
- Syndromic/chromosomal diagnoses and major comorbidities significantly increase G-tube placement risk.
- Cardiac, respiratory, neurological issues, and lower esophageal sphincter problems are key risk factors, often more influential than syn/chrom alone.
- These findings aid in identifying high-risk infants and optimizing non-surgical feeding interventions before considering G-tubes.
Objectives:
To review data on a cohort of infants with cleft palate to (1) determine rates of gastrostomy (G)-tube placement, (2) identify contributing comorbidities, and (3) use relative risk analyses to improve management of cleft palate in infants with feeding difficulty.
Design:
Retrospective medical record review.
Setting:
Tertiary care children's hospital.
Patients:
Infants with cleft palate born between January 1, 2000, and December 31, 2008, without G-tubes prior to referral were included. Comorbidities were analyzed, including syndromes and chromosomopathies (syn/chrom) and cardiac, respiratory, neurologic, and gastrointestinal diagnoses. These comorbidities were analyzed independently.
Main Outcome Measure:
Gastrostomy-tube placement.
Results:
Of 214 infants with cleft palate, 34 required G-tubes. Of these, 19 had syn/chrom. Independent of these diagnoses, 17 infants had 1 system comorbidity and 12 had multisystem comorbidities. Of the 180 patients without G-tubes, 20 had syn/chrom. Independent of these diagnoses, 10 infants had 1 system comorbidity and 2 had multisystem comorbidities. Rates of G-tube placement ranged from 3% in infants without any comorbidity to 94% in infants with respiratory comorbidity. Relative risks of G-tube placement with syn/chrom, 1 system comorbidity, and multisystem comorbidities were 5.68 (95% confidence interval, 3.18-10.16), 21.79 (8.76-54.17), and 29.66 (12.18-72.21), respectively.
Conclusions:
Diagnosis of syn/chrom or major comorbidity significantly increases risk of G-tube placement. Regardless of syn/chrom association, problems affecting the heart, respiratory system, central nervous system, and lower esophageal sphincter are the most significant risk factors, implying that particular comorbidities are more influential than a simple diagnosis of syn/chrom. These data should help identify children at greatest risk for G-tubes and those expected to overcome feeding difficulties, leading to more persistent use of nonsurgical therapy before resorting to G-tubes.
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