Related Experiment Video
Updated: Jun 3, 2026

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
Published on: February 10, 2026
C1q nephropathy presenting as acute renal failure
Pavan Malleshappa1, Ravi Ranganath, Anup P Chaudhari
1Department of Nephrology, Lilavati Hospital and Research Centre, Mumbai, India. dr_pavanm@yahoo.co.in
C1q nephropathy, a kidney disease, can cause acute renal failure. This case study shows that intensive steroid treatment effectively resolved proteinuria and achieved remission in a patient with C1q nephropathy.
Area of Science:
- Nephrology
- Immunopathology
Background:
- C1q nephropathy is a rare glomerular disease characterized by C1q deposition in the kidney.
- It can present with nephrotic syndrome or acute kidney injury, often mimicking other glomerulonephritides.
Observation:
- A 42-year-old male presented with high-grade fever and acute renal failure necessitating hemodialysis.
- Renal biopsy showed focal proliferative glomerulonephritis with dominant mesangial C1q deposition and electron-dense deposits.
Findings:
- The patient was diagnosed with C1q nephropathy, excluding systemic lupus erythematosus.
- Treatment with methylprednisolone pulse and oral prednisolone resulted in complete remission and proteinuria resolution.
Implications:
- This case highlights the efficacy of intensive immunosuppressive therapy in managing C1q nephropathy.
- Early diagnosis and prompt treatment may improve renal outcomes in C1q nephropathy patients.
More Related Videos
08:44Elucidation of the Material Basis of Yiqi Qingjie Formula Against IgA Nephropathy Using UHPLC-Q-Orbitrap HRMS Integrated with Network Pharmacology
Published on: May 19, 2026
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Related Concept Videos
Acute Kidney Injury I: Introduction
Acute Kidney Injury II: Pathophysiology
Acute Pyelonephritis I: Introduction
Nephrotic Syndrome I : Introduction
Acute Kidney Injury III: Clinical Manifestations
Nephrons