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Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Signal and System01:26

Signal and System

A signal x(t) is a set of data or a time function representing a variable of interest. Signals typically convey information about a phenomenon, such as atmospheric temperature, humidity, human voice, television images, a dog's bark, or birdsongs. More generally, a signal can be a function of more than one independent variable. For instance, images depend on horizontal and vertical positions and can be regarded as two-dimensional signals. However, this text will focus on one-dimensional signals...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Updated: Jun 3, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

What is systems biology?

Rainer Breitling1

  • 1Faculty of Biomedical and Life Sciences, University of Glasgow Scotland, UK. r.breitling@bio.gla.ac.uk

Frontiers in Physiology
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Systems biology is a growing field, but its core concepts remain unclear to many. This perspective clarifies its aims, distinguishes it from related activities, and highlights its essential connection to synthetic biology.

Keywords:
computational modelingsynthetic biologysystems biology

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Last Updated: Jun 3, 2026

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The Use of Chemostats in Microbial Systems Biology
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Published on: October 14, 2013

Area of Science:

  • Systems biology
  • Synthetic biology
  • Biological sciences

Background:

  • Systems biology is gaining prominence, yet its definition and scope are not widely understood within the biological community.
  • Clarifying the core principles of systems biology is essential for its effective integration and advancement.

Purpose of the Study:

  • To elucidate the fundamental concepts and motivations driving systems biology research.
  • To delineate the boundaries of systems biology by identifying activities outside its core focus.
  • To explore and define the critical relationship between systems biology and synthetic biology.

Main Methods:

  • Conceptual analysis of systems biology principles.
  • Comparative discussion of related biological research activities.
  • Exploration of the interdependencies between systems and synthetic biology.

Main Results:

  • Identification of the aesthetic drivers motivating systems biologists.
  • Distinction between core systems biology activities and peripheral endeavors.
  • Establishment of synthetic biology as a key application and driver for systems biology.

Conclusions:

  • Systems biology is defined as the foundational scientific endeavor supporting the advancement of synthetic biology.
  • A clear understanding of systems biology is crucial for the successful development and application of synthetic biology.