Related Experiment Video
Updated: Jun 3, 2026

10:08
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
Published on: May 18, 2022
Centenarians Today: New Insights on Selection from the 5-COOP Study
Jean-Marie Robine1, Siu Lan Karen Cheung, Yasuhiko Saito
1National Institute on Health and Medical Research, INSERM, 75654 Paris, France.
Current Gerontology and Geriatrics Research
|March 23, 2011
Summary
The oldest old population is growing, but at different rates globally. This study reveals varying mortality selection levels in Denmark, France, Japan, Switzerland, and Sweden, impacting oldest-old health.
Area of Science:
- Demography
- Gerontology
- Public Health
Background:
- The population of individuals aged 90 and above has significantly increased globally.
- The growth rate of the oldest old population varies considerably across different countries.
- Understanding mortality patterns in this demographic is crucial for public health planning.
Purpose of the Study:
- To quantify and compare mortality selection levels among nonagenarians and centenarians in five low-mortality nations.
- To identify country-specific differences in survival probabilities for the oldest old.
- To lay the groundwork for future research on health status trade-offs within the 5-Country Oldest Old Project (5-COOP).
Main Methods:
- Utilized data from the Human Mortality Database for Denmark, France, Japan, Switzerland, and Sweden.
- Incorporated specific data for Japan's centenarian population.
- Analyzed demographic data to assess mortality selection differentials.
Main Results:
- Identified three distinct levels of mortality selection across the studied countries.
- Observed a milder mortality selection in Japan.
- Found stronger mortality selection in Denmark and Sweden, with intermediate levels in France and Switzerland.
Conclusions:
- Significant variations in mortality selection exist among the oldest old in developed countries.
- These differences provide a basis for investigating the relationship between mortality selection and functional health outcomes.
- The findings support the ongoing research within the 5-Country Oldest Old Project (5-COOP).
Related Concept Videos
Longitudinal Research
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Longitudinal Studies
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
Aging
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Life Tables
A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
Applications of Life Tables
Life tables are versatile across various fields, providing a quantitative basis for analyzing mortality and survival rates. Whether used by demographers, actuaries, epidemiologists, or sociologists, life tables offer valuable insights into the dynamics of life and death, facilitating informed decisions in public health, insurance, conservation, and beyond. Their broad applicability highlights the interconnectedness of demographic data with practical outcomes in everyday life and strategic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
