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Related Concept Videos

Testes: Histology01:27

Testes: Histology

A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Testes: Gross Anatomy01:19

Testes: Gross Anatomy

The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...

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Related Experiment Video

Updated: Jun 3, 2026

Protocol for Single-Cell Dissociation, RNA Sequencing, and Isolation of Myoepithelial Cells and Fibroblasts from the Aged Lacrimal and Salivary Glands
08:37

Protocol for Single-Cell Dissociation, RNA Sequencing, and Isolation of Myoepithelial Cells and Fibroblasts from the Aged Lacrimal and Salivary Glands

Published on: April 24, 2026

Correlations between intralobular interstitial morphological changes and epithelial changes in ageing testis.

O T Pop1, Corina Gabriela Cotoi, I E Pleşea

  • 1Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Romania.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Aging testicular tissue shows stromal changes, particularly seminiferous tubule wall sclerosis, potentially causing epithelial degeneration. Capillary networks remain largely unchanged with age.

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Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids
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Protocol for Single-Cell Dissociation, RNA Sequencing, and Isolation of Myoepithelial Cells and Fibroblasts from the Aged Lacrimal and Salivary Glands
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Published on: April 24, 2026

Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids
09:18

Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids

Published on: October 7, 2020

Area of Science:

  • Reproductive biology
  • Gerontology
  • Histopathology

Background:

  • Testicular aging involves complex morphologic changes in the seminiferous epithelium and surrounding stroma.
  • Understanding these age-related alterations is crucial for reproductive health and understanding age-associated pathologies.

Purpose of the Study:

  • To investigate the influence of intra-lobular stromal morphologic changes on seminiferous epithelium during aging.
  • To correlate specific stromal alterations with seminiferous epithelium involution and degenerative changes.

Main Methods:

  • Histological analysis of testicular tissue from 192 prostate cancer patients aged 50-80 years.
  • Staining with HE, Goldner, Gömöri, and immunohistochemistry for smooth muscle actin, collagen IV, and CD34.
  • Evaluation of seminiferous tubule wall sclerosis, intra-lobular septa, Leydig cells, arteriolae, and capillary networks.

Main Results:

  • Seminiferous epithelium involution was uneven, with degenerative changes primarily at the lobular periphery.
  • Seminiferous tubule wall focal sclerosis, including fibro-hyaline collars, was observed but not age-related.
  • Intra-lobular septal changes and Leydig cell hyperplasia were present but showed no significant age trend.
  • Capillary networks exhibited no significant quantitative endothelial changes across age groups, except a decrease in very old cases.

Conclusions:

  • Seminiferous tubule wall focal sclerosis may contribute to focal seminiferous epithelium degeneration in aging testes.
  • While stromal changes occur, they do not uniformly correlate with age, suggesting multifactorial influences on testicular senescence.