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Updated: Jun 3, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
[Etiology and pathogenesis of overactive bladder].
T Bschleipfer1, F Wagenlehner, W Weidner
1Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen, Justus-Liebig-Universität Gießen, Rudolf-Buchheim-Straße 7, 35392 Gießen, Deutschland. Th.B@gmx.de
Der Urologe. Ausg. A
|March 23, 2011
Summary
Overactive bladder (OAB) affects many adults and has complex causes. This study highlights circulatory disorders as a potential, under-investigated factor in OAB pathogenesis.
Area of Science:
- Urology
- Pathophysiology
- Nephrology
Context:
- Overactive bladder (OAB) impacts over 10% of adults, presenting a complex multifactorial etiology.
- Common causes like infections, cancer, and neurogenic disorders (detrusor overactivity, DO) are well-known.
- Non-neurogenic factors including bladder outlet obstruction and pelvic floor dysfunction also contribute significantly to OAB.
Purpose:
- To explore the under-recognized role of circulatory disorders in the pathogenesis of OAB.
- To emphasize the need for further investigation into the molecular changes of bladder afferents and circulatory system in OAB patients.
Summary:
- OAB etiology is multifactorial, involving neurogenic and non-neurogenic conditions.
- Circulatory disorders are proposed as a significant, yet under-investigated, etiological factor in OAB.
- Further research is needed on bladder afferent molecular changes and circulatory issues in OAB.
Impact:
- Highlights a novel area for OAB research, potentially leading to new diagnostic and therapeutic strategies.
- Encourages a broader consideration of etiological factors beyond traditional urological and neurological perspectives.
- Aims to improve the understanding and management of overactive bladder syndrome.
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