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Updated: Jun 3, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Etiology and risk factors of infantile wheezing]
Miao-Miao Yao1, Ke-Ming Wang, Qun-Ying Xu
1Department of Pediatircs, Bo'ai Hospital of Zhongshan, Nanfang Medical University, Zhongshan, Guangdong 528403, China. miaomiao-yao@163.com
Objective:
To study the etiology and risk factors of infantile wheezing.
Methods:
The clinical data of 180 infants with wheezing were retrospectively studied. The risk factors for wheezing attacks were investigated by logistic regression analysis.
Results:
Viral infection (33.3%) was the most common cause for wheezing attacks, followed by asthma (19.4%), parental smoking and special environments (15.6%), gastroesophageal reflux disease (12.8%), premature delivery (7.8%), Mycoplasma infection (6.7%), and bronchopulmonary dysplasia (4.4%). The multivariate logistic regression analysis showed 7 factors that significantly correlated with wheezing attacks: allergic history of parents, sensitization to alimentary or inspiratory allergens, viral or Mycoplasma infection, premature delivery and special environments.
Conclusions:
The commonest cause of infantile wheezing is viral infection, followed by asthma. Genetic factors, individual atopic constitution and environmental factors play important roles in wheezing attacks.
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