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[Changes of high-sensitivity CRP and insulin sensitivity index in children with obstructive sleep apnea hypopnea
1Department of Pediatrics, Third Shenzhen People's Hospital, Guangdong Medical University, Shenzhen, Guangdong 518112, China. docdlk@tom.com
Insights
Children with obstructive sleep apnea hypopnea syndrome (OSAHS) show elevated high-sensitivity C-reactive protein (hsCRP) levels. This increase in hsCRP may indicate a higher risk of cardiovascular disease in these children.
Area of Science:
- Pediatric Sleep Medicine
- Cardiovascular Risk Factors
- Inflammatory Markers
Context:
- Obstructive sleep apnea hypopnea syndrome (OSAHS) is increasingly recognized in children.
- Inflammation is a key factor in the development of cardiovascular diseases.
- Biomarkers for early detection of cardiovascular risk are crucial in pediatric populations.
Purpose:
- To determine high-sensitivity C-reactive protein (hsCRP) and insulin sensitivity index (ISI) levels in children diagnosed with OSAHS.
- To compare these markers between children with OSAHS and those with primary snoring (PS).
Summary:
- Children with OSAHS exhibited significantly higher apnea-hypopnea index (AHI) and lower lowest oxygen saturation (LSaO2) compared to the PS group.
- Elevated hsCRP levels were observed in the OSAHS group, correlating negatively with LSaO2.
- No significant differences in ISI or serum lipids were found between the groups.
Impact:
- The findings suggest that elevated hsCRP is associated with OSAHS in children.
- Increased hsCRP may serve as an indicator of heightened cardiovascular disease risk in pediatric OSAHS.
- This research highlights the importance of monitoring inflammatory markers in children with sleep-disordered breathing.
Objective:
To investigate the levels of high-sensitivity CRP (hsCRP) and insulin sensitivity index (ISI) in children with obstructive sleep apnea hypopnea syndrome (OSAHS).
Methods:
Twenty-nine children with OSAHS and 22 children with primary snoring (PS) were enrolled. Polysomnography was performed. Body mass index (BMI), hsCRP, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured. ISI was calculated.
Results:
The apnea hypopnea index (AHI) in the OSAHS group was higher than that in the PS group (13.2 ± 9.2 vs 1.2 ± 1.1; P<0.05). The lowest oxygen saturation (LSaO2) in the OSAHS group was lower than that in the PS group [(78.5 ± 5.4)% vs (87.4 ± 3.7)%; P<0.05]. The values of hsCRP in the OSAHS group was higher than those in the PS group (2.8 ± 2.7 mg/L vs 0.6 ± 0.9 mg/L; P<0.05). There were no significant differences in the ISI and serum lipids between the two groups. The hsCRP level was negatively correlated with LSaO2 in the OSAHS group (r=-0.531, P<0.05).
Conclusions:
The hsCRP level increases in children with OSAHS. The increased hsCRP level might be associated with an increased risk of cardiovascular diseases.
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