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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: Jun 3, 2026

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[Study on MYOC/TIGR gene mutations in primary open-angle glaucoma].

Jian-Hua Chen1, Liang Xu, Yang Li

  • 1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100005, China. chenjh6688@yahoo.com.cn

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|March 24, 2011
PubMed
Summary
This summary is machine-generated.

The trabecular meshwork induced-glucocorticoid response protein gene (TIGR/MYOC) mutations were studied in Chinese primary open-angle glaucoma (POAG) patients. The G12R mutation was more common in POAG patients, while the novel I288M mutation was not associated with POAG.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Context:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness globally.
  • Genetic factors play a significant role in the pathogenesis of POAG.
  • The trabecular meshwork induced-glucocorticoid response protein (TIGR/MYOC) gene is a known contributor to POAG development.

Purpose:

  • To investigate mutations within the coding sequence of the TIGR/MYOC gene in Chinese patients diagnosed with POAG.
  • To identify novel or known MYOC gene variants and assess their association with POAG in the Chinese population.

Summary:

  • A case-control study screened 118 Chinese POAG patients and 150 controls for MYOC gene mutations using PCR, SSCP, and DNA sequencing.
  • Three coding sequence variants were identified: a novel I288M mutation and previously reported G12R and Y353I.
  • The G12R mutation was significantly more frequent in POAG patients (P=0.037), while I288M and Y353I showed no significant association with POAG.
  • Overall, MYOC mutations were found in 4.23% of sporadic POAG patients.

Impact:

  • Identifies G12R as the most common MYOC mutation in Chinese POAG patients.
  • Suggests that approximately 4.23% of sporadic POAG cases in this population may be linked to mutations in the MYOC gene.
  • Highlights the importance of genetic screening for MYOC mutations in the diagnosis and understanding of POAG in Chinese individuals.