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Chisomicines A-C, limonoids from Chisocheton ceramicus.
Ibrahim A Najmuldeen1, A Hamid A Hadi, Khalijah Awang
1Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Journal of Natural Products
|March 25, 2011
Summary
Researchers discovered three new limonoids, chisomicines A-C, from Chisocheton ceramicus bark. Chisomicine A showed dose-dependent inhibition of nitric oxide (NO) production in immune cells.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Organic Chemistry
Background:
- Chisocheton ceramicus is a plant source of bioactive compounds.
- Limonoids are a class of terpenoids with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new limonoids from Chisocheton ceramicus.
- To evaluate the biological activity of the isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using 2D NMR, CD spectroscopy, and X-ray crystallography.
- Assessment of nitric oxide (NO) production inhibitory activity in vitro.
Main Results:
- Three new limonoids, designated chisomicines A-C (1-3), were identified.
- The structures of chisomicines A-C were fully determined.
- Chisomicine A demonstrated dose-dependent inhibition of NO production in LPS-stimulated J774.1 cells while maintaining high cell viability.
Conclusions:
- Chisocheton ceramicus bark is a source of novel limonoids.
- Chisomicine A possesses significant NO production inhibitory properties, suggesting potential anti-inflammatory applications.
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