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Updated: Aug 6, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Induced pemphigus caused by occupational contact with Basochrom]
N Tsankov1, L Stransky, M Kostowa
1Institut für Dermatologie und Venerologie der Medizinischen Akademie Sofia.
Dermatosen in Beruf Und Umwelt. Occupation and Environment
|May 1, 1990
Summary
Occupational exposure to basic chromium sulfate caused a rare autoimmune blistering disease, induced pemphigus, in a 25-year-old man. This case highlights chromium sulfate
Area of Science:
- Dermatology
- Occupational Health
- Immunology
Background:
- Occupational contact dermatitis can manifest in various forms.
- Chromium compounds are known industrial sensitizers.
Observation:
- A 25-year-old man developed a vesiculobullous eruption on the scalp, body, and oral/nasal mucosa.
- Symptoms appeared after occupational contact with basochrom (basic chromium sulfate).
Findings:
- Clinical presentation, histological examination, and immunological data were analyzed.
- The condition was diagnosed as an occupationally induced pemphigus.
Implications:
- This case underscores the potential for basic chromium sulfate to induce autoimmune blistering diseases.
- Awareness among occupational health professionals is crucial for early diagnosis and prevention.
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