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Related Experiment Video

Updated: Jun 3, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Episodic memory retrieval, parietal cortex, and the default mode network: functional and topographic analyses.

Carlo Sestieri¹, Maurizio Corbetta, Gian Luca Romani

¹Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. c.sestieri@unich.it

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|March 25, 2011

Summary

The default mode network (DMN) shows functional differences during memory retrieval. Some DMN regions activate for retrieval, while others, like the medial prefrontal cortex, deactivate, indicating functional heterogeneity.

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Area of Science:

Neuroscience
Cognitive Neuroscience

Background:

The default mode network (DMN) is typically viewed as a homogeneous system for internal cognition.
Its interaction with other networks during specific cognitive processes like episodic memory retrieval is not fully understood.

Purpose of the Study:

To investigate the functional topography and response profiles of parietal regions within and outside the DMN during episodic memory retrieval.
To determine if the DMN is functionally homogeneous or heterogeneous during memory retrieval.

Main Methods:

Utilized functional magnetic resonance imaging (fMRI) to study brain activity.
Independently defined DMN regions using task-evoked deactivations and resting-state functional connectivity.
Analyzed parietal regions' activity and connectivity during episodic memory retrieval.

Main Results:

Episodic memory retrieval activated posterior DMN nodes (e.g., angular gyrus) and non-DMN parietal regions.
DMN regions showed earlier response peaks compared to sustained responses in non-DMN regions.
A functional dissociation was observed within the DMN, with anterior medial prefrontal cortex deactivating during retrieval.

Conclusions:

Parietal DMN regions directly support memory retrieval, while non-DMN regions are involved in post-retrieval decision-making.
The DMN exhibits functional heterogeneity, not homogeneity, during episodic memory retrieval.