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High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease

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Acute-phase proteins: As diagnostic tool.

Sachin Jain¹, Vidhi Gautam, Sania Naseem

¹Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Jabalpur (MP) - 482 001, India.

Journal of Pharmacy & Bioallied Sciences

|March 25, 2011

Summary

This summary is machine-generated.

The acute-phase response involves host reactions to injury, with acute-phase proteins (APP) aiding repair and immunity. These proteins can serve as diagnostic tools for various animal diseases, improving health monitoring.

Keywords:

Acute-phase proteins C-reactive protein diagnosis haptoglobin serum amyloid A

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Area of Science:

Veterinary Medicine
Immunology
Biochemistry

Background:

The acute-phase response is a host's reaction to infection, inflammation, or trauma.
It involves pathophysiological changes like fever, leukocytosis, and altered hormones to minimize damage and promote healing.

Purpose of the Study:

To explain the role of proinflammatory cytokines in stimulating hepatic acute-phase protein (APP) production.
To detail the functions of positive acute-phase proteins in host defense and repair.
To highlight the diagnostic potential of APPs in various animal diseases.

Main Methods:

Review of literature on the acute-phase response and acute-phase proteins.
Analysis of the mechanisms of APP production and function.
Examination of APP applications in disease diagnosis.

Main Results:

Proinflammatory cytokines stimulate hepatic production of APPs.
Positive APPs are crucial for trapping pathogens, activating complement, clearing cellular debris, neutralizing enzymes, and modulating immune responses.
APP levels correlate with various conditions including infections and neoplasia.

Conclusions:

Acute-phase proteins play vital roles in host defense and tissue repair.
APP measurement offers a valuable diagnostic approach for monitoring animal health and disease.
Further research into APP utility can enhance veterinary diagnostics.