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Updated: Jun 3, 2026
Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
SST-2 tumor inoculation is a useful model for studying the anti-tumor immune response in SHR rats
Naomi Nishio1, Katsutaka Oishi, Kazuhiko Machida
1Department of Hygiene and Public Health School of Human Sciences, Waseda University, 2-579-15, Mikajima, 359-1192, Tokorozawa, Saitama, Japan, m67235@human.waseda.ac.jp.
Objective:
The purpose of the present study was to investigate the relation between the dose of tumor cell inoculation (especially the doses less than minimum required to evoke tumor growth) and the anti-tumor immune system, particularly lymphoblast formation and cytotoxic activity of lymphcytes.
Method:
We inoculated rats with various doses of SST-2 tumor cells and examined natural killer (NK) cell activity and lymphoblast formationin vitro.
Result:
The results showed that the cytotoxicities against SST-2 cells and lymphoblast formation of lymphocytes were enhanced by small dose inoculation of tumor cells that could not induce tumor growth.
Conclusion:
It was suggested that was lymphocutes play an important role as an anti-tumor immune system at small doses of tumor inoculation, which appears to reflect an early stage of tumor growthin vivo. It was also suggested that SST-2 tumor inoculation might be a useful model for studying the anti-tumor immune response in SHR rats.
