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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
Published on: August 8, 2014
Pre-existing periodontitis exacerbates experimental arthritis in a mouse model
Melissa D Cantley1, David R Haynes, Victor Marino
1Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, Adelaide, SA, Australia.
Journal of Clinical Periodontology
|March 26, 2011
Summary
Pre-existing periodontitis worsened experimental arthritis (EA) in mice, increasing severity and progression. This research highlights the significant impact of gum disease on rheumatoid arthritis development.
Area of Science:
- Oral health and immunology
- Rheumatology research
- Animal modeling
Background:
- Rheumatoid arthritis (RA) is linked to increased alveolar bone loss.
- Periodontitis elevates the risk of developing RA.
- An animal model is needed to study the periodontitis-RA connection.
Purpose of the Study:
- To establish an animal model for assessing the relationship between periodontitis and experimental arthritis (EA).
- To investigate how pre-existing periodontitis influences the development and severity of EA.
Main Methods:
- Periodontitis was induced in mice using Porphyromonas gingivalis.
- Experimental arthritis (EA) was induced using the collagen antibody-induced arthritis model.
- Micro-CT, histology, and immunohistochemistry were used to assess bone and joint changes.
Main Results:
- Mice with periodontitis exhibited more severe and rapidly progressing EA.
- Periodontitis alone led to bone loss in the radiocarpal joint.
- EA alone also resulted in alveolar bone loss.
Conclusions:
- Pre-existing periodontitis significantly exacerbates experimental arthritis in a mouse model.
- This study provides a valuable animal model for further research into the interplay between periodontitis and arthritis.
