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Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)
Published on: August 31, 2018
Biomolecular interaction study of Cyclolinopeptide A with human serum albumin
Ben Rempel1, Bo Gui, Jason Maley
1Department of Biochemistry, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5.
Journal of Biomedicine & Biotechnology
|March 26, 2011
Abstract:
The kinetics, energetics, and structure of Cyclolinopeptide A binding with Human Serum Albumin were investigated with surface plasmon resonance and circular dichroism. The complex is formed through slow recognition kinetics that is temperature sensitive in the range of 20°C-37°C. The overall reaction was observed to be endothermic (ΔH = 204 kJ mol(-1)) and entropy driven (ΔS = 746 J mol(-1)K(-1)) with overall small changes to the tertiary structure.

