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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Cardiovascular profile in patients with obstructive sleep apnea
Fátima Dumas Cintra1, Sergio Tufik, Angelo de Paola
1Departamento de Psicobiologia, Universidade Federal de São Paulo, SP, Brazil. fatimacintra@cardiol.br
Arquivos Brasileiros De Cardiologia
|March 26, 2011
Summary
Obstructive Sleep Apnea (OSA) is linked to obesity, hypertension, low HDL, and enlarged left atrium. Early identification of these cardiovascular markers is crucial for managing OSA risks.
Area of Science:
- Cardiology
- Sleep Medicine
- Internal Medicine
Background:
- Obstructive Sleep Apnea (OSA) is a significant risk factor for cardiovascular diseases and mortality.
- Understanding the cardiovascular effects of sleep-disordered breathing is vital for clinical assessment.
Purpose of the Study:
- To investigate and characterize the cardiovascular profile of patients diagnosed with Obstructive Sleep Apnea.
Main Methods:
- Prospective study of 261 OSA patients and 108 controls from March 2007 to March 2009.
- Utilized polysomnography, blood tests, physical exams, ECG, spirometry, cardiopulmonary exercise testing, and echocardiography.
- Study registered on clinicaltrials.gov (NCT00768625) and approved by the Research Ethics Committee.
Main Results:
- OSA patients commonly exhibited obesity, hypertension, and low high-density lipoprotein (HDL) levels.
- A statistically significant increase in left atrial diameter was observed in OSA patients compared to controls (p = 0.001).
- These cardiovascular characteristics increased the likelihood of OSA by 16.6%, irrespective of reported symptoms.
Conclusions:
- The primary cardiovascular profile associated with OSA in this cohort includes obesity, hypertension, low HDL, and increased left atrial diameter.
- These findings highlight key cardiovascular markers for identifying and managing patients with Obstructive Sleep Apnea.
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