Definitions of breakthrough disease and second-line agents
James J Marriott1, Paul W O'Connor
1Section of Neurology, University of Manitoba, GF-543 Health Sciences Centre, 820 Sherbrook Street, Winnipeg, MB, Canada, R3A 1R9.
Neurologic Clinics
|March 29, 2011
Abstract:
Conventional disease-modifying agents are only moderately effective, so breakthrough disease activity is commonly seen. The evidence from randomized clinical trials and real-world observational data supporting the use of the second-line agents natalizumab, mitoxantrone, and cyclophosphamide are reviewed. Potential future treatment options are also discussed. Management algorithms for breakthrough disease are outlined.
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