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Related Experiment Video

Updated: Jun 3, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Cognitive function in families with exceptional survival.

Sandra Barral¹, Stephanie Cosentino, Rosann Costa

¹The Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA.

Neurobiology of Aging

|March 29, 2011

Summary

This summary is machine-generated.

Cognitive function may predict longevity. Individuals with a family history of exceptional survival showed better performance on attention, working memory, and semantic tasks compared to controls.

Related Experiment Videos

Last Updated: Jun 3, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Area of Science:

Genetics
Neuroscience
Gerontology

Background:

Exceptional survival is a complex trait influenced by genetic and environmental factors.
Endophenotypes are measurable biological traits linked to genetic predispositions for disease or health.
Cognitive function is a potential endophenotype for longevity, but requires further investigation.

Purpose of the Study:

To investigate if cognitive function serves as an endophenotype for longevity.
To compare cognitive performance in individuals with a family history of exceptional survival against controls.

Main Methods:

A family-based cohort study (Long Life Family Study - LLFS) of 1380 individuals from 283 families.
Cognitive performance was assessed using digit forward/backward and verbal fluency tasks.
Comparison between LLFS offspring/siblings and their spouses (controls).

Main Results:

LLFS offspring and siblings scored significantly higher on digit forward (p=5x10⁻⁵) and backward (p=8x10⁻⁴) tasks.
LLFS participants also performed significantly better on a verbal fluency task (p=0.008).
No significant differences were observed in other cognitive tests.

Conclusions:

Cognitive performance, particularly in attention, working memory, and semantic processing, is enhanced in individuals with a family history of exceptional survival.
These findings support cognitive function as a potential endophenotype for longevity.
Further research can explore the genetic and biological underpinnings of this association.