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Sensory and motor peripheral nerve function and incident mobility disability.

Rachel E Ward1, Robert M Boudreau, Paolo Caserotti

  • 1Spaulding Rehabilitation Hospital, Cambridge, Massachusetts; School of Public Health, Boston University, Boston, Massachusetts.

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Poor sensorimotor nerve function, including nerve impairments and symptoms, significantly predicts mobility disability in older adults. Interventions like strength training may help prevent disability and improve function.

Keywords:
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Area of Science:

  • Gerontology
  • Neurology
  • Epidemiology

Background:

  • Sensorimotor nerve function is crucial for mobility in older adults.
  • Mobility disability is a significant public health concern in aging populations.
  • Understanding predictors of mobility loss is essential for developing targeted interventions.

Purpose of the Study:

  • To investigate the association between sensorimotor nerve function and the development of mobility disability over a 10-year period.
  • To identify specific nerve function parameters that predict future mobility limitations.

Main Methods:

  • A prospective cohort study was conducted with a population-based sample of 2,148 community-dwelling older adults.
  • Sensorimotor nerve function was assessed using motor nerve conduction, sensory testing (monofilaments, vibration), and lower extremity symptoms.
  • Incident mobility disability was defined as self-reported difficulty or inability to walk or climb stairs over 8.5 years.

Main Results:

  • 55% of participants exhibited nerve impairments, and 30% developed mobility disability.
  • Worse motor nerve amplitude, vibration detection threshold, and lower extremity symptoms were significant predictors of mobility disability.
  • Multiple nerve impairments (two or more) substantially increased the risk of developing mobility disability.

Conclusions:

  • Poor sensorimotor nerve function is an independent predictor of incident mobility disability in older adults.
  • Interventions targeting modifiable risk factors, such as strength training, should be explored to prevent mobility loss.
  • Further research is needed to develop effective strategies for preserving function in older adults with compromised nerve function.