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Updated: Jun 3, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
Biomarkers in the critically ill patient: C-reactive protein
Jean-Louis Vincent1, Katia Donadello, Xavier Schmit
1Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, 808, route de Lennik, 1070, Brussels, Belgium. jlvincen@ulb.ac.be
Abstract:
Levels of C-reactive protein (CRP), an acute phase protein, are elevated in many inflammatory conditions and are used to detect and follow disease in many fields of medicine, including rheumatology, gastroenterology, and cardiology. CRP concentrations are also used in critically ill patients, notably because they are increased during the inflammatory response to infection, that is, sepsis. However, CRP is not specific for sepsis, and serum CRP concentrations need to be interpreted in the context of a full clinical examination and the presence of other signs and symptoms of sepsis.
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