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Related Experiment Video

Updated: Jun 3, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

Triggering receptor expressed on myeloid cell 1.

Damien Barraud¹, Sébastien Gibot

¹Medical ICU, University Hospital of Nancy, Avenue de Lattre de Tassigny, 54000 Nancy, France.

Critical Care Clinics

|March 29, 2011

Summary

Diagnosing sepsis is challenging due to unreliable clinical signs and negative lab tests. Measuring soluble triggering receptor expressed on myeloid cell 1 (TREM-1) in bodily fluids may aid in infection diagnosis.

Area of Science:

Critical Care Medicine
Immunology
Infectious Diseases

Background:

Sepsis is a significant cause of illness and death in intensive care units.
Current sepsis diagnostic methods lack sufficient sensitivity and specificity.
Microbiological studies for sepsis diagnosis frequently yield negative results.

Purpose of the Study:

To evaluate the diagnostic potential of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1) in biological fluids.
To explore sTREM-1 as a biomarker for infection, particularly sepsis.

Main Methods:

The study focuses on the assessment of soluble TREM-1 levels.
Expression of TREM-1 on phagocytic cells in response to microbial presence was investigated.
Analysis of sTREM-1 in various biological fluids was performed.

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Main Results:

TREM-1 expression increases on phagocytic cells during bacterial or fungal infections.
Soluble TREM-1 levels in biological fluids show potential as diagnostic markers.
The study highlights the utility of sTREM-1 for infection detection.

Conclusions:

Soluble TREM-1 assessment offers a promising approach for diagnosing infections like sepsis.
sTREM-1 may overcome limitations of current diagnostic strategies.
Further research into sTREM-1 utility in clinical settings is warranted.