Related Experiment Video
Updated: Jun 3, 2026
07:25
Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
Skin involvement in Susac's syndrome
Guillaume Turc1, Dominique Monnet, Nicolas Dupin
1Pole Raymond Garcin, Department of Neurology, Hôpital Sainte-Anne, Paris and Paris Descartes University, Inserm UMR 894, France. g.turc@ch-sainte-anne.fr
Journal of the Neurological Sciences
|March 29, 2011
Summary
Susac's syndrome (SS), a rare condition affecting brain, retina, and inner ear, can also involve the skin. This case highlights skin biopsy findings consistent with SS, suggesting it is a systemic disease.
Area of Science:
- Neurology
- Ophthalmology
- Dermatology
- Rheumatology
Background:
- Susac's syndrome (SS) is a rare autoimmune endotheliopathy affecting the brain, retina, and inner ear.
- It is characterized by microangiopathy of precapillary arterioles.
Observation:
- A 24-year-old male presented with encephalopathy, retinal artery occlusions, and hearing loss.
- Livedo racemosa preceded neurological and auditory symptoms by two weeks.
- Skin biopsies revealed arteriolar thrombi and inflammation, mirroring findings in SS.
Findings:
- Histological examination of skin lesions confirmed findings consistent with Susac's syndrome.
- The patient experienced complete recovery with corticosteroid treatment.
- Follow-up MRI revealed characteristic "holes" in the centro-callosal region.
Implications:
- This case demonstrates that Susac's syndrome can manifest with skin involvement.
- Skin examination should be considered in the diagnostic workup of suspected SS.
- Findings support SS as a systemic vasculopathy with potential multi-organ impact.
More Related Videos
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:19Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...