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Updated: Jun 3, 2026

Study of Cell Migration in Microfabricated Channels
Published on: February 21, 2014
A semi-stochastic cell-based formalism to model the dynamics of migration of cells in colonies
1Delft Institute of Applied Mathematics, Delft University of Technology, Delft, The Netherlands. F.J.Vermolen@tudelft.nl
Abstract:
We consider the movement and viability of individual cells in cell colonies. Cell movement is assumed to take place as a result of sensing the strain energy density as a mechanical stimulus. The model is based on tracking the displacement and viability of each individual cell in a cell colony. Several applications are shown, such as the dynamics of filling a gap within a fibroblast colony and the invasion of a cell colony. Though based on simple principles, the model is qualitatively validated by experiments on living fibroblasts on a flat substrate.
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