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Updated: Jun 3, 2026
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
[Effect of Campath-1H induction on immunosuppression in small intestine transplantation]
Jian Zhou1, Wei-Qiang Ju, Xiao-Shun He
1Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. gdtrc@163.com
Objective:
To investigate the effect of Campath-1H induction on immunosuppression in small intestine transplantation.
Methods:
Clinical data of a patient who underwent small intestine transplantation were retrospectively summarized.
Results:
Intraoperative Campath-1H induction by intravenous injection was administered. Triple immunosuppression(FK506, MMF and methylprednisolone) was used postoperatively. The lymphocyte and leukocyte decreased significantly following Campath-1H induction, and returned to normal after adjusting the dose of immunosuppressant and use of colony stimulating factor. There were no acute rejection, graft versus host disease, or severe infection during the immediate postoperative period. The patient recovered and discharged.
Conclusion:
Intraoperative Campath-1H induction and postoperative triple immunosuppression using FK506, MMF, and methylprednisolone may prevent rejection and graft versus host disease in the early stage after small intestine transplantation.
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