Related Experiment Video
Updated: Jun 3, 2026

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research
Published on: August 31, 2013
[Central nervous system infection--tick-borne encephalitis, neuroborreliosis or both?]
Antti Varis1, Jarmo Oksi, Hannu Järveläinen
1TYKS:n sisätautien klinikka, Turku.
Abstract:
Certain tick species are able to transmit both tick-borne encephalitis (TBE) and Lyme borreliosis. Therefore, it is possible that a patient can simultaneously be infected with the TBE-virus and Borrelia burgdorferi-spirochete as a result of a single tick bite. Although this is a rare event, its possibility has to be taken into account e.g. in the diagnostics of febrile patients who suffer from symptoms typical of meningoencephalitis and who live or come from endemic tick regions. This is because the treatments of these two infectious diseases differ from each other--there is a specific treatment only for Lyme borreliosis. We describe two Finnish patients with double infection with TBE and neuroborreliosis.
Insights
Simultaneous infection with tick-borne encephalitis (TBE) and Lyme borreliosis is possible from a single tick bite. Early diagnosis is crucial as treatments differ for these rare co-infections.
Area of Science:
- * Infectious Diseases
- * Neurology
- * Public Health
Background:
- * Some tick species can transmit multiple pathogens, including tick-borne encephalitis (TBE) virus and Borrelia burgdorferi, the causative agent of Lyme borreliosis.
- * Co-infection presents diagnostic and therapeutic challenges due to differing treatment protocols.
Observation:
- * Two Finnish patients presented with simultaneous infections of TBE and neuroborreliosis following a single tick bite.
- * Clinical presentation included symptoms indicative of meningoencephalitis.
Findings:
- * Confirmed co-infection with TBE virus and Borrelia burgdorferi in the described cases.
- * Highlights the importance of considering co-infection in differential diagnoses for febrile patients in endemic areas.
Implications:
- * Clinicians in endemic regions should consider co-infection in patients with meningoencephalitis symptoms.
- * Accurate diagnosis is essential for appropriate and timely treatment, particularly as only Lyme borreliosis has a specific treatment.
- * Further research into the prevalence and clinical impact of such co-infections is warranted.
Related Concept Videos
Arboviral Encephalitis
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
Rocky Mountain Spotted Fever
Bacterial Meningitis
Bacterial Meningitis II: Pathophysiology

