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Related Experiment Video

Updated: Jun 3, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Published on: June 16, 2023

Isolated left ventricular apical hypoplasia.

Thomas E Vanhecke¹, Jeffrey Decker, Nicholas Leonowicz

¹Department of Cardiovascular Medicine, William Beaumont Hospital, Royal Oak, MI, USA. tvanhecke@gmail.com

Congenital Heart Disease

|March 30, 2011

Summary

Isolated left ventricular apical hypoplasia is a rare congenital heart defect. Cardiac MRI reveals a truncated left ventricle, myocardial deficiency, and altered right ventricle anatomy.

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Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

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Published on: June 16, 2023

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

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Murine Fetal Echocardiography

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Published on: February 15, 2013

Area of Science:

Cardiology
Congenital Heart Disease
Medical Imaging

Background:

Isolated left ventricular (LV) apical hypoplasia is a recently identified congenital cardiac anomaly.
Understanding its distinct morphological features is crucial for diagnosis and management.

Observation:

This condition presents with a truncated, spherical LV and rightward septal bulging.
Key features include myocardial deficiency at the LV apex with adipose infiltration.
The right ventricle elongates, wrapping around the underdeveloped LV apex.

Findings:

Cardiac magnetic resonance imaging (CMR) effectively visualizes the characteristic features of LV apical hypoplasia.
The study details the anatomical abnormalities, including papillary muscle origin and septal deviation.

Implications:

Accurate diagnosis via CMR is essential for appropriate patient care.
Further research into the etiology and long-term outcomes of this rare condition is warranted.
This work contributes to the understanding of congenital heart abnormalities.