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Updated: Jun 3, 2026

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
Published on: December 23, 2013
Interactions of topiramate with polyethylene glycol 8000 in solid state with formation of new polymorph
Noymi Yam1, Xiaoling Li, Bhaskara R Jasti
1University of the Pacific, Thomas J Long School of Pharmacy & Health Sciences, 3601 Pacific Avenue, Stockton, CA 95211, United States.
Abstract:
Topiramate [2,3:4,5-bis-O-(1-methylethylidene) β-D-fructo-pyranose sulfamate] was found to form a new polymorphic form in the presence of polyethylene glycol 8000 (PEG). Comparative study of the solid state interactions of PEG and structural topiramate analogue lacking sulfamate group (Diacetone D-fructose) indicated that the sulfamate moiety was essential for the formation of the new polymorph. The drug-polymer interactions were investigated using differential s canning calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and hot stage microscopy. The new polymorphic form was characterized using variable temperature powder X-ray diffraction (VTPXRD) and solid state Nuclear Magnetic Resonance (ssNMR). The new polymorph was found to form only in the presence of PEG at specific weight ratios.
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