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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

Which growth criteria better predict fetal programming?

Sandra S Mattos1, Maria Elizabeth C Chaves, Suzana Maria Ramos Costa

  • 1Maternal-Fetal Cardiac Unit, Royal Portuguese Hospital, Av Portugal 163, Recife, PE 50090-900, Brazil. ssmattos@cardiol.br

Archives of Disease in Childhood. Fetal and Neonatal Edition
|March 30, 2011
PubMed
Summary

Customised (ct) growth criteria better predict adverse intrauterine environments than standard (st) criteria. This approach, combined with maternal biochemistry, aids in screening for fetal programming complications.

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Area of Science:

  • Perinatology
  • Neonatal Medicine
  • Biochemistry

Background:

  • Intrauterine growth restriction is linked to adverse neonatal outcomes.
  • Standard growth criteria may not accurately identify all fetuses experiencing suboptimal intrauterine environments.
  • Biochemical markers in maternal and cord blood offer insights into fetal well-being.

Purpose of the Study:

  • To compare the efficacy of customised (ct) versus standard (st) growth criteria in predicting intrauterine insult.
  • To evaluate the association between growth status and specific biochemical markers.
  • To explore the potential of combined growth criteria and maternal biochemistry for screening fetal programming.

Main Methods:

  • A cohort of 32 mothers and their term neonates were classified using both standard and customised growth criteria.
  • Maternal and cord blood samples were analyzed for nitric oxide, high-sensitive C-reactive protein (hs-CRP), uric acid, lipids, and proteins.
  • Neonates were categorized as small for gestational age (SGA), appropriate for gestational age (AGA), or large for gestational age (LGA).

Main Results:

  • Customised criteria identified more neonates as small for gestational age (ct-SGA) compared to standard criteria (st-SGA).
  • Both st-SGA and ct-SGA neonates exhibited elevated nitric oxide and hs-CRP levels, with mothers showing lower albumin fractions.
  • Elevated uric acid and triglyceride levels were observed in ct-LGA neonates and their mothers, respectively.

Conclusions:

  • Customised growth criteria demonstrate superior ability in identifying neonates exposed to unfavorable intrauterine conditions.
  • Maternal biochemical profiles, when integrated with customised growth assessments, can serve as a valuable tool for screening adverse fetal programming.
  • These findings suggest a refined approach to neonatal risk assessment during pregnancy.