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Updated: Jun 3, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
A causative link between periodontal disease and glomerulonephritis: a preliminary study
Mohammad Reza Ardalan1, Kamyar Ghabili, Reza Pourabbas
1Department of Nephrology, Dialysis, and Transplantation.
Therapeutics and Clinical Risk Management
|March 30, 2011
Summary
Periodontal disease may play a role in glomerulonephritis. Treating periodontitis in patients with unknown glomerulonephritis improved urine protein excretion and reduced C-reactive protein levels, suggesting a potential link.
Area of Science:
- Nephrology
- Periodontology
- Internal Medicine
Background:
- Periodontal disease is linked to systemic conditions, with high prevalence in chronic kidney disease.
- The association between periodontal disease and glomerulonephritis remains unexplored.
Purpose of the Study:
- To evaluate the severity of periodontitis in patients with unexplained primary glomerulonephritis.
- To investigate the potential role of periodontitis in the pathogenesis of glomerulonephritis.
Main Methods:
- Ten patients with unknown primary glomerulonephritis and stable renal function were enrolled.
- Periodontal disease severity was assessed using plaque index (PI), gingival index (GI), and periodontal pocket depth (PD).
- Patients received dental treatment, ACE inhibitors/ARBs, and were monitored for renal function, proteinuria, and C-reactive protein (CRP) after six months.
Main Results:
- Most patients presented with advanced periodontal disease (median PI 57.5%, PD 4.3 mm, GI 1.1).
- Periodontal therapy led to a significant reduction in urine protein excretion (P=0.008).
- Four patients showed a negative C-reactive protein (CRP) conversion post-treatment.
Conclusions:
- A potential causative relationship between periodontal disease and glomerulonephritis is suggested.
- Periodontal treatment may positively impact renal parameters and inflammation in glomerulonephritis patients.
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