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Related Experiment Video

Updated: Jun 3, 2026

Electrochemotherapy of Tumours

Electrochemotherapy of Tumours

Published on: December 15, 2008

Clinical trials for solid tumors using electrochemotherapy.

R Heller¹, R Gilbert, M J Jaroszeski

¹Department of Surgery, College of Medicine, University of South Florida, Tampa, FL.

Methods in Molecular Medicine

|March 30, 2011

Summary

This summary is machine-generated.

Chemotherapy has low response rates because cancer drugs struggle to enter cells. Enhancing cell membrane permeability could improve chemotherapy effectiveness for various cancers, including melanoma.

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Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

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Last Updated: Jun 3, 2026

Electrochemotherapy of Tumours

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Published on: December 15, 2008

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

Area of Science:

Oncology
Cancer Biology
Pharmacology

Background:

Chemotherapy is a cornerstone cancer treatment, but often suffers from low patient response rates.
Intracellular drug action is frequently limited by the cell membrane barrier, hindering treatment efficacy.
Melanoma exhibits particularly low response rates, with partial responses between 20-45% and complete responses under 5%.

Purpose of the Study:

To investigate methods for improving chemotherapy efficacy.
To explore the potential of increasing cell membrane permeability to enhance drug delivery.
To address the low response rates observed in various cancers, using melanoma as a model.

Main Methods:

Review of existing literature on chemotherapy and cell membrane transport.
Analysis of factors limiting intracellular drug penetration.
Exploration of biophysical or chemical methods to increase cell membrane permeability.

Main Results:

Cell membrane permeability is a critical factor limiting the effectiveness of many chemotherapeutic agents.
Strategies to enhance membrane permeability show potential for improving drug uptake.
Targeting membrane permeability could overcome a significant barrier in cancer treatment.

Conclusions:

Improving cell membrane permeability is a promising strategy to enhance chemotherapy effectiveness.
Further research into membrane-permeabilizing agents could lead to improved cancer therapies.
Overcoming the cell membrane barrier may significantly increase response rates in difficult-to-treat cancers.