Related Experiment Video
Updated: Jun 3, 2026
14:23
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
[CD4+CD25+Foxp3+ T lymphocytes: naturally occuring regulatory T cells]
Monika Ryba1, Jolanta Myśliwska
1Zaklad Immunologii, Katedra Immunologii, Gdanski Uniwersytet Medyczny, Gdansk. akinomab@gumed.edu.pl
Pediatric Endocrinology, Diabetes, and Metabolism
|March 31, 2011
Summary
Naturally occurring regulatory T cells (Tregs) suppress immune responses. The transcription factor Foxp3 is crucial for Treg development and function, acting as a key indicator of their suppressive activity.
Area of Science:
- Immunology
- Cell Biology
Context:
- Regulatory T cells (Tregs) are vital for immune system regulation.
- Tregs constitute 5-10% of peripheral CD4+ lymphocytes.
- They are identified by high, constant expression of the IL-2 receptor α subunit (CD25).
Purpose:
- To elucidate the role of regulatory T cells (Tregs) in immune suppression.
- To highlight the significance of the transcription factor Foxp3 in Treg function.
Summary:
- Regulatory T cells (Tregs) are crucial for immunosuppression and immune regulation.
- These cells express high levels of CD25, distinguishing them from conventional lymphocytes.
- The transcription factor Foxp3 is essential for Treg development and function, serving as a specific marker for their suppressive activity.
Impact:
- Understanding Treg mechanisms is key to developing immunotherapies.
- Foxp3's role provides insights into controlling immune responses.
- This research deepens our knowledge of immune homeostasis and tolerance.
Related Concept Videos
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:22T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
01:27Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...