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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
LbL coated microcapsules for delivering lipid-based drugs
Elena M Shchukina1, Dmitry G Shchukin
1Institute of Bioorganic Chemistry, Minsk, Belarus.
Advanced Drug Delivery Reviews
|March 31, 2011
Summary
Layer-by-layer assembly offers a precise method for encapsulating poorly water-soluble drugs. This technique is promising for developing advanced drug delivery systems for lipid-based compounds.
Area of Science:
- Drug Delivery Systems
- Materials Science
- Pharmaceutical Technology
Background:
- Over 40% of new pharmacologically active compounds face challenges due to poor water solubility.
- Effective administration and delivery methods are crucial for these compounds.
- Lipid-based drugs often require specialized delivery solutions.
Purpose of the Study:
- To review the application of layer-by-layer assembly for lipid-based drug delivery.
- To highlight the potential of this technology in overcoming solubility issues.
- To explore various formulations utilizing this technique.
Main Methods:
- Layer-by-layer (LbL) assembly for controlled encapsulation.
- Step-wise adsorption based on electrostatic attraction.
- Formation of multilayer shells with nanometer precision.
Main Results:
- LbL assembly enables precise control over shell thickness and composition.
- The technique is applicable to various delivery systems like emulsions and nanoparticles.
- Successful encapsulation of lipid-based drugs is demonstrated.
Conclusions:
- Layer-by-layer assembly is a highly promising technology for developing drug delivery systems for poorly soluble compounds.
- This method offers precise control for creating advanced formulations.
- It addresses a significant challenge in modern pharmacotherapy.
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