Related Experiment Video
Updated: Jun 3, 2026

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate (NMDA) Receptor in Blood
Published on: January 9, 2018
pH-Responsive chromogenic-sensing molecule based on bis(indolyl)methene for the highly selective recognition of
Litao Wang1, Xiaoming He, Yong Guo
1Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China.
Abstract:
Bis(indolyl)methene displays high selectivity and sensitivity for aspartate and glutamate in water-containing medium based on the proton transfer signaling mode. The presence of acid can easily induce proton transfer to the basic H-bond acceptor moiety, which modulates the internal charge transfer state of the bis(indolyl)methene skeleton and gives rise to dramatic change in color. The detection limits for aspartate and glutamate were 0.80 ppm and 1.12 ppm, respectively.
