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Related Concept Videos

Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 3, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

Rhenium(IV) compounds inducing apoptosis in cancer cells.

José Martínez-Lillo1, Teresa F Mastropietro, Rosamaria Lappano

  • 1Centro di Eccellenza CEMIF.CAL, Dipartimento di Chimica, Università della Calabria, via P. Bucci 14/c, 87030 Arcavacata di Rende, Cosenza, Italy.

Chemical Communications (Cambridge, England)
|March 31, 2011
PubMed
Summary

This study reveals that novel mononuclear Rhenium(IV) compounds exhibit significant anticancer properties. These compounds show potent in vitro antiproliferative activity against various cancer cell lines, highlighting their therapeutic potential.

Related Experiment Videos

Last Updated: Jun 3, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Cancer Research

Background:

  • Metal-based compounds are increasingly explored for their therapeutic potential.
  • Rhenium complexes, particularly Rhenium(IV), are emerging as promising candidates in oncology.
  • Understanding the structure-activity relationship of novel metal complexes is crucial for drug development.

Purpose of the Study:

  • To synthesize and characterize a series of novel mononuclear Rhenium(IV) compounds.
  • To evaluate the in vitro anticancer properties of these compounds.
  • To investigate the antiproliferative effects of Rhenium(IV) complexes with different bipyridine and phenanthroline ligands.

Main Methods:

  • Synthesis of mononuclear Re(IV) compounds with the general formula ReCl(4)L, where L represents 2,2'-bipyridine (bpy), 2,2'-bipyrimidine (bpym), 4,4'-dimethyl-2,2'-bipyridine (dmbpy), and 1,10-phenanthroline (phen).
  • In vitro antiproliferative assays using selected cancer cell lines.
  • Spectroscopic and analytical characterization of the synthesized compounds.

Main Results:

  • All synthesized mononuclear Re(IV) compounds demonstrated significant in vitro antiproliferative activity.
  • The compounds exhibited potent activity against a range of tested cancer cell lines.
  • The study represents the first investigation into the anticancer properties of this specific series of Re(IV) complexes.

Conclusions:

  • The investigated mononuclear Re(IV) compounds possess potent anticancer properties.
  • These Rhenium(IV) complexes are promising candidates for further development as novel anticancer agents.
  • Further research is warranted to explore their mechanism of action and in vivo efficacy.