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Updated: Jun 3, 2026
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Eight months of continuous positive airway pressure (CPAP) decrease tumor necrosis factor alpha (TNFA) in men with
Andrea Hegglin1, Otto D Schoch, Wolfgang Korte
1Geriatrische Klinik, Kompetenzzentrum Gesundheit und Alter, St. Gallen, Switzerland.
Sleep & Breathing = Schlaf & Atmung
|March 31, 2011
Summary
Continuous positive airway pressure (CPAP) therapy for 8 months reduced serum tumor necrosis factor alpha (TNFA) in men with sleep apnea. This effect was observed regardless of CPAP adherence levels.
Area of Science:
- Pulmonary Medicine
- Immunology
- Sleep Medicine
Background:
- Sleep apnea syndrome is associated with elevated inflammatory markers.
- Tumor necrosis factor alpha (TNFA) plays a role in systemic inflammation.
Purpose of the Study:
- To evaluate the impact of continuous positive airway pressure (CPAP) therapy on serum TNFA levels.
- To assess changes in TNFA after 8 months of CPAP treatment in patients with sleep apnea.
Main Methods:
- Prospective, observational clinical trial involving 66 patients with newly diagnosed sleep apnea syndrome.
- Serum TNFA concentrations were measured at baseline and after a mean of 7.8 months of CPAP therapy using an ultrasensitive ELISA assay.
- Patient adherence to CPAP was recorded in hours per night.
Main Results:
- Serum TNFA levels significantly decreased in men, irrespective of their CPAP adherence (high or low).
- No significant reduction in TNFA was observed in women treated with CPAP.
- A positive correlation was found between the average hours of CPAP use and the change in TNFA levels in men.
Conclusions:
- Long-term CPAP therapy demonstrates a positive effect on reducing serum TNFA levels in male patients with sleep apnea.
- The anti-inflammatory benefits of CPAP on TNFA in men persist even with suboptimal adherence.
- Further research may be needed to explore the differential response observed in women.
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