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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

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Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
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Published on: September 30, 2020

[Delirium in the elderly].

K Singler1, B Singler, H J Heppner

  • 1Medizinische Klinik 2, Geriatrie, Klinikum Nürnberg. katrin.singler@klinikum-nuernberg.de

Deutsche Medizinische Wochenschrift (1946)
|March 31, 2011
PubMed
Summary
This summary is machine-generated.

Delirium affects 20-50% of elderly patients over 65. This article reviews new clinical aspects and guidelines for managing this common geriatric syndrome.

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Area of Science:

  • Geriatric Medicine
  • Clinical Neurology

Context:

  • Delirium is prevalent in 20-50% of hospitalized elderly patients.
  • Advanced age (>65 years) is a significant risk factor for delirium development.
  • Delirium is a common and critical condition in geriatric medicine.

Purpose:

  • To provide an overview of new aspects concerning delirium in the clinical setting.
  • To highlight recent advancements in understanding and managing delirium in older adults.
  • To inform healthcare professionals about current clinical contexts of delirium.

Summary:

  • The article reviews the latest clinical insights into delirium, a condition affecting a substantial portion of elderly inpatients.
  • It references key 2010 clinical guidelines: NICE guideline 103 and the German S3-Leitlinie.
  • Focuses on new developments relevant to the diagnosis, prevention, and management of delirium.

Impact:

  • Aims to improve the clinical management of delirium in elderly populations.
  • Enhances awareness of updated guidelines for healthcare providers.
  • Contributes to better patient outcomes by disseminating current knowledge on delirium.