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Related Concept Videos

Two Components: Liquid–Liquid Systems01:27

Two Components: Liquid–Liquid Systems

A pressure-composition phase diagram explicitly describes the behavior of an ideal solution of two volatile liquids under varying pressures and compositions. A pressure-composition diagram has two main curves. The bubble point curve represents the plot of pressure versus liquid mole fraction. It indicates the pressure at which the first bubble of vapor forms from the liquid phase as the system pressure decreases.The dew point curve is the pressure versus vapor mole fraction. It indicates the...

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Related Experiment Video

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Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
10:54

Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR

Published on: February 23, 2016

Dynamic nuclear polarization system output volume reduction using inert fluids.

Eric T Peterson1, Jeremy W Gordon, Matthew G Erickson

  • 1Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. etpeterson@wisc.edu

Journal of Magnetic Resonance Imaging : JMRI
|March 31, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a method to increase hyperpolarized compound concentration for preclinical use. By using a perfluorocarbon-water mixture, researchers can achieve higher concentrations suitable for small animal studies.

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Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Medical Imaging
  • Preclinical Research

Background:

  • Dynamic Nuclear Polarization (DNP) enhances NMR signal sensitivity.
  • Current DNP methods yield hyperpolarized compounds at concentrations not ideal for preclinical applications.
  • Preclinical studies require higher concentrations of hyperpolarized agents for effective imaging.

Purpose of the Study:

  • To develop a method for increasing the concentration of hyperpolarized compounds from a commercial DNP polarizer.
  • To adapt the DNP polarization process for improved suitability in preclinical applications.
  • To enable higher concentrations of hyperpolarized agents for small animal studies.

Main Methods:

  • Utilized a HyperSense DNP polarizer.
  • Investigated the use of a perfluorocarbon and water mixture for dissolving hyperpolarized material.
  • Employed a dissolution temperature of 1.4K, suitable for injection.

Main Results:

  • Replacing 75% of water with an inert, immiscible perfluorocarbon reduced the injection volume four-fold.
  • Rapid separation of the perfluorocarbon-water mixture allowed quick collection of the aqueous layer.
  • Achieved significantly increased concentrations of hyperpolarized compounds.

Conclusions:

  • The developed approach yields higher concentrations of hyperpolarized compounds in injection-suitable volumes.
  • This method is effective for (13)C-labeled pyruvic acid and succinate.
  • The technique is potentially applicable to various nuclei and compounds polarized via DNP.