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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronization therapy in paediatric and congenital heart disease patients

Annelies E van der Hulst1, Victoria Delgado, Nico A Blom

  • 1Department of Paediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

European Heart Journal
|April 1, 2011
PubMed

Insights

Cardiac resynchronization therapy (CRT) shows promise for congenital heart disease (CHD) patients with heart failure. Echocardiography can identify mechanical dyssynchrony to guide CRT selection in this heterogeneous population.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Biomedical Engineering

Background:

  • Congenital heart disease (CHD) patient numbers are rising, with heart failure being a leading cause of mortality.
  • Cardiac resynchronization therapy (CRT) offers potential benefits for heart failure in CHD and pediatric populations.
  • The heterogeneity of CHD anatomical substrates complicates CRT efficacy.

Purpose of the Study:

  • To review the role of CRT in pediatric and CHD patients experiencing heart failure.
  • To evaluate current CRT inclusion criteria and outcomes across diverse anatomical subgroups.
  • To discuss echocardiographic assessment of mechanical dyssynchrony for predicting CRT response.

Main Methods:

  • Review of existing literature on CRT in CHD and pediatric heart failure.
  • Analysis of current CRT inclusion criteria and outcomes in various CHD anatomical subtypes.
  • Comprehensive discussion of echocardiographic methods for assessing mechanical dyssynchrony.

Main Results:

  • CRT is a potential therapeutic option for heart failure in CHD and pediatric patients.
  • Patient heterogeneity and specific anatomical features significantly impact CRT effectiveness.
  • Echocardiography, particularly novel tools, aids in assessing cardiac dyssynchrony for CRT candidate selection.

Conclusions:

  • CRT may improve clinical outcomes for pediatric and CHD patients with heart failure.
  • Tailoring CRT based on individual anatomy and dyssynchrony assessment is crucial for success.
  • Echocardiography plays a vital role in optimizing CRT application in this population.

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