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Updated: Jun 3, 2026

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
Published on: April 11, 2025
Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities
Cees van Kooten1, Giovanna Lombardi, Kyra A Gelderman
1Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. kooten@lumc.nl
Abstract:
Dendritic cells are the key component to regulate and coordinate adaptive immune responses, including tolerance. This overview will briefly summarize different strategies to generate tolerogenic dendritic cell and the in vivo use of these cells in experimental transplantation models. We discuss some obstacles and possible solutions including alternative strategies for the use of negative vaccination in the context of organ transplantation.
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