Advances in human cytochrome p450 and personalized medicine
Qi Chen1, Tao Zhang, Jing-Fang Wang
1State Key Laboratory of Microbial Metabolism, Luc Montagnier Biomedical Research Institute, and College of Life Sciences and Biotechnology, China.
Abstract:
Among all the drug metabolic enzymes, cytochrome P450 (CYP450) superfamily acts as an important role responsible for the oxidation of almost 90% currently used drugs. As variations of Single Nucleotide Polymorphism (SNPs) in human CYP450 genes will cause different drug effects and even adverse effects, studies on SNPs of human CYP450 genes can be used for indicating the most possible genes associated with human diseases and relevant therapeutic targets, predicting the drug efficacy and adverse drug response, investigating individual gene specific properties and then providing personalized and optimal clinic therapies. Recently, some new bioinformatics methods are introduced in SNPs researches, which significantly facilitate the development of drug and medicine. The review will focus on a brief introduction of the SNPs of human drug metabolic enzymes and their relationships with personalized medicine. Besides, common bioinformatics analysis methods and some latest progresses and applications in this area will also be discussed.
Related Concept Videos
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenetics of Drug Metabolism: Overview
Pharmacogenomics: Identification of New Drug Targets
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

