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C-reactive protein decrease after postbariatric abdominoplasty.

Wilson Cintra1, Miguel Modolin, Joel Faintuch

  • 1Plastic Surgery Service, Hospital das Clinicas, Sao Paulo, Sao Paulo, 05403-900, Brazil.

Inflammation
|April 2, 2011
PubMed
Summary

Abdominoplasty surgery may offer metabolic benefits, improving HDL cholesterol and reducing C-reactive protein levels. This study highlights potential advantages of abdominal fat removal in weight-stable patients post-bariatric surgery.

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Area of Science:

  • Metabolic Surgery
  • Plastic Surgery
  • Inflammation Research

Background:

  • Patients undergoing bariatric surgery often experience significant weight loss.
  • Post-bariatric surgery, excess abdominal fat can remain, prompting interest in aesthetic procedures.
  • Metabolic and inflammatory profiles are crucial indicators of overall health post-weight loss.

Purpose of the Study:

  • To investigate the metabolic and inflammatory effects of abdominoplasty after substantial weight loss.
  • To assess long-term changes in glucose homeostasis, lipid profiles, and systemic inflammation following abdominal fat removal.
  • To determine if abdominoplasty offers additional metabolic advantages beyond bariatric surgery.

Main Methods:

  • Prospective study comparing abdominoplasty (n=20) with augmentation mammoplasty/mastopexy (n=20) in premenopausal females post-Roux-en-Y gastric bypass.

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  • Monitoring of BMI, white blood cell count, C-reactive protein, hemoglobin, lipid profile, glucose, and HbA1c.
  • Long-term follow-up averaging over 20 months for both groups.

    • Main Results:

    • Abdominoplasty patients showed an increase in HDL cholesterol and a decrease in C-reactive protein.
    • Metabolic and inflammatory indices remained stable post-bariatric surgery in both groups.
    • No significant changes were observed in BMI, white blood cell count, hemoglobin, total cholesterol, triglycerides, glucose, or HbA1c attributed to abdominoplasty.

    Conclusions:

    • Abdominoplasty may confer metabolic and anti-inflammatory benefits in weight-stable patients after bariatric surgery.
    • The observed improvements in HDL cholesterol and C-reactive protein suggest a positive impact of abdominal fat removal.
    • This study provides the first long-term evidence in a weight-stable population supporting these abdominoplasty-associated metabolic advantages.