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Updated: Jun 3, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Are cardiomyocytes able to generate pre-amyloid peptides?
Anna Fidziańska1, Ewa Walczak, Paweł Bekta
1Neuromuscular Unit, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. neurmyol@cmdik.pan.pl
Abstract:
We performed ultrastructural testing of a cardiac biopsy taken from a heart with amyloidosis in which transthyretin mutation and light chain A amyloidosis were excluded. Cardiomyocytes of the affected heart showed accumulation of endosomal-like structures in which soluble amyloid oligomeric conformation was deposited. Intracellular accumulation of β -amyloid as well as phosphorylated tau protein seen in the immunohistochemical study suggest that the heart tissue may generate an amyloidogenic peptide leading to cardiomyocyte destruction and heart dysfunction.
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