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[Acne and its drug treatment]
1Dermatologische Universitätsklinik Basel.
Therapeutische Umschau. Revue Therapeutique
|August 1, 1990
Summary
Acne vulgaris, a common pilosebaceous disease, stems from abnormal follicular keratinization. Treatments target pathogenic factors, with oral isotretinoin effective for severe acne but contraindicated in women of childbearing age due to teratogenicity.
Area of Science:
- Dermatology
- Pathology
Context:
- Acne vulgaris is the most common pilosebaceous follicle disease.
- The primary defect is abnormal follicular keratinization leading to retention hyperkeratosis and comedones.
Purpose:
- To outline the pathogenesis of acne vulgaris.
- To review current and advanced treatment modalities for acne vulgaris.
Summary:
- Acne vulgaris pathogenesis involves abnormal keratinization, forming comedones as precursor lesions to inflammatory papules, pustules, and nodules.
- Current topical treatments include tretinoin, benzoyl peroxide (a potent antibacterial), and topical antibiotics like erythromycin and clindamycin.
- Oral 13-cis retinoic acid (isotretinoin) represents a significant advance for severe acne but carries teratogenic risks.
Impact:
- Provides a comprehensive overview of acne vulgaris pathophysiology and treatment.
- Highlights the efficacy and risks associated with isotretinoin therapy for severe acne cases.