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Updated: Jun 3, 2026

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
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Transport and sensing in nanofluidic devices.

Kaimeng Zhou1, John M Perry, Stephen C Jacobson

  • 1Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, USA.

Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|April 5, 2011
PubMed
Summary

Nanofluidic devices enable precise ion transport and sensing, leveraging unique nanoscale phenomena for advanced analytical applications. These systems utilize micro- and nanofabrication for tailored functionalities and particle characterization.

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Area of Science:

  • Physics
  • Chemistry
  • Materials Science

Background:

  • Nanofluidics explores ion transport and sensing in nanoscale channels.
  • Unique phenomena like double-layer overlap and entropic forces dominate at the nanoscale.
  • Micro- and nanofabrication enable precise control over channel dimensions and functionalities.

Purpose of the Study:

  • To review fundamental nanofluidic architectures and transport properties.
  • To discuss the application of nanofluidic systems in analytical sensing.
  • To highlight particle characterization using resistive-pulse sensing.

Main Methods:

  • Utilizing micro- and nanofabrication techniques for device construction.
  • Investigating ion transport phenomena in single and multiple nanochannels.

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Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales
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Last Updated: Jun 3, 2026

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Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
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  • Employing resistive-pulse sensing for single particle analysis.

    • Main Results:

    • Nanofluidic systems exhibit distinct transport behaviors compared to microfluidic systems.
    • Fabrication techniques allow for complex, integrated nanofluidic devices.
    • Resistive-pulse sensing provides a method for characterizing individual particles.

    Conclusions:

    • Nanofluidics offers unique opportunities for ion transport and sensing.
    • Advanced fabrication enables sophisticated nanofluidic device designs.
    • Nanofluidic devices hold significant potential for analytical applications.