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Updated: Jun 3, 2026
10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Apical infection spreading to adjacent teeth: a case report.
Takashi Komabayashi1, Jin Jiang, Qiang Zhu
1Department of Endodontics, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX 75246, USA. tkomabayashi@bcd.tamhsc.edu
Summary
This case report details a rare apical infection that spread to adjacent teeth, leading to devitalization. Successful regenerative therapy using advanced materials healed the large bone defect, restoring tooth vitality and function.
Area of Science:
- Endodontics
- Oral Surgery
- Regenerative Dentistry
Background:
- Apical periodontitis can lead to significant tooth damage and bone loss.
- Adjacent teeth can be affected by the spread of infection from a primary source.
- Regenerative endodontic procedures offer potential for healing large periapical lesions.
Observation:
- A 25-year-old female presented with uncontrolled apical infection on tooth #24, affecting adjacent teeth #23 and #25.
- Histopathology revealed a periapical cyst, while surgical findings indicated a periapical abscess with purulence.
- The patient underwent root-end surgery and regenerative therapy for teeth #23, #24, and #25.
Findings:
- Regenerative therapy involved Mineral Trioxide Aggregate, Bio-Oss xenograft, and Bio-Gide membrane.
- The patient experienced symptom resolution post-treatment.
- Radiographic follow-ups at 6 months, 1 year, and 2 years demonstrated satisfactory healing of the apical lesion and bone defect.
Implications:
- Highlights the importance of accurate pulpal and apical diagnosis in endodontics.
- Emphasizes bacterial control to prevent apical periodontitis exacerbation.
- Demonstrates the efficacy of regenerative materials in healing extensive periapical bone defects.
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