Related Experiment Video
Updated: Aug 8, 2026
Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
Conscious atrial appendectomized rats have a blunted atrial natriuretic factor release to volume expansion but normal
1National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.
Abstract:
The release of atrial natriuretic factor (ANF) after various acute stimuli was studied in conscious chronic bilaterally atrial appendectomized (APP) rats. The response to acute volume expansion was markedly blunted (+67% v +357% in controls, P less than .01). However, the response to norepinephrine infusion was only moderately reduced (+107% v +212%, P less than .05) and the response to acute salt load was identical to that in normal controls (+148% v +180%, P = NS). These results demonstrate that APP rats can increase the secretion of ANF, at least to some acute stimuli. This indicates that the stores of ANF available for release are not significantly depleted after atrial appendectomy.
