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Related Concept Videos

Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Structures of the Endocrine System00:59

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...

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γ Chain transducing element: a shared pathway between endocrine and immune system.

Ilaria Vigliano1, Anna Fusco, Loredana Palamaro

  • 1Department of Pediatrics, Unit of Immunology, Federico II University, via S. Pansini 5-80131, Naples, Italy.

Cellular Immunology
|April 5, 2011
PubMed
Summary
This summary is machine-generated.

The common cytokine receptor gamma c (γc) is crucial for immune cell function and links the endocrine and immune systems. It acts as a shared signaling molecule for both cytokine and growth hormone receptors.

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Area of Science:

  • Immunology
  • Endocrinology
  • Molecular Biology

Background:

  • Primary immunodeficiencies often stem from intracellular communication molecules, primarily in hematopoietic cells.
  • The gamma c (γc) protein's abundance suggests broad effects beyond the immune system.
  • The immune and endocrine systems coordinate via soluble mediators for effective responses.

Purpose of the Study:

  • To review the role of γc as a shared signaling molecule.
  • To highlight the functional link between the endocrine and immune systems mediated by γc.
  • To explore how shared receptor components integrate cellular pathways.

Main Methods:

  • Literature review focusing on γc's function.
  • Analysis of molecular interactions between cytokine and growth hormone receptors.
  • Examination of γc's role in cellular signaling pathways.

Main Results:

  • γc is a common transducing element for multiple cytokine receptors.
  • A novel dependence of growth hormone (GH) signaling on γc in specific cell types was identified.
  • This dependence supports an interplay between endocrine and immune system signaling.

Conclusions:

  • γc serves as a critical link between the immune and endocrine systems.
  • Shared receptor components like γc are key to understanding integrated cellular control.
  • Further research into these molecular links can illuminate physiological and pathological conditions.