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The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
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B cells - ontogenesis and immune memory development

Zuzana Nescakova1, Slavomir Bystricky

  • 1Institute of Chemistry, Glycomed Centre, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia. chemnesc@savba.sk

General Physiology and Biophysics
|April 5, 2011
PubMed

Functional diversity in the distinct developmental stages as well as anti-pathogen effectiveness and memory functionality make B cells unique and attractive object of physiology studies of the immune system. B cells are produced throughout the life of an organism, originate from the hematopoietic stem cells before birth and continue to differentiate to terminal stages. Over the past decade, there has been considerable progress in the research of all B cell intermediates and developmental processes. In this review, we will try to bring brief and comprehensive description of the current understanding of this fascinating topic.

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